InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sele

Summary

InnateDB Gene

IDBG-202283.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sele

Gene Name

selectin, endothelial cell

Synonyms

CD62E; E-selectin; Elam

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026582

Encoded Proteins

IDBP-202285

selectin, endothelial cell

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 9006914

[Homo sapiens] SELE is upregulated by TNF alpha during inflammatory responses and activated by RELA, NFKB2, JUN and ATF2.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000007908:
The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:164048234-164057677

Strand

Forward strand

Band

H2.2

Transcripts

ENSMUST00000027874

ENSMUSP00000027874

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	4 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0030246	carbohydrate binding
GO:0033691	sialic acid binding
GO:0043274	phospholipase binding
GO:0070492	oligosaccharide binding

Biological Process

GO:0002092	positive regulation of receptor internalization
GO:0002687	positive regulation of leukocyte migration
GO:0007157	heterophilic cell-cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007165	signal transduction
GO:0007202	activation of phospholipase C activity
GO:0030029	actin filament-based process
GO:0050901	leukocyte tethering or rolling
GO:0070555	response to interleukin-1

Cellular Component

GO:0005615	extracellular space
GO:0005901	caveola
GO:0005905	coated pit
GO:0016021	integral component of membrane
GO:0030863	cortical cytoskeleton
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm