InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sele

Summary

InnateDB Protein

IDBP-202285.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sele

Protein Name

selectin, endothelial cell

Synonyms

CD62E; E-selectin; Elam;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027874

InnateDB Gene

IDBG-202283 (Sele)

Protein Structure

UniProt Annotation

Function

Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	4 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0030246	carbohydrate binding
GO:0033691	sialic acid binding
GO:0043274	phospholipase binding
GO:0070492	oligosaccharide binding

Biological Process

GO:0002092	positive regulation of receptor internalization
GO:0002687	positive regulation of leukocyte migration
GO:0007157	heterophilic cell-cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007165	signal transduction
GO:0007202	activation of phospholipase C activity
GO:0030029	actin filament-based process
GO:0050901	leukocyte tethering or rolling
GO:0070555	response to interleukin-1

Cellular Component

GO:0005615	extracellular space
GO:0005901	caveola
GO:0005905	coated pit
GO:0016021	integral component of membrane
GO:0030863	cortical cytoskeleton
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:98278

InterPro

IPR000436 Sushi/SCR/CCP
IPR000742 Epidermal growth factor-like domain
IPR001304 C-type lectin
IPR001881 EGF-like calcium-binding domain
IPR002396 Selectin superfamily
IPR016187 C-type lectin fold

PFAM

PF00084
PF00008
PF00059
PF07645

PRINTS

PR00343

PIRSF

SMART

SM00032
SM00181
SM00034
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt