InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Il18bp

Summary

InnateDB Gene

IDBG-202395.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il18bp

Gene Name

interleukin 18 binding protein

Synonyms

Igifbp; IL-18BP; MC54L

Species

Mus musculus

Ensembl Gene

ENSMUSG00000070427

Encoded Proteins

IDBP-202397

interleukin 18 binding protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137496:
The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn\'s disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:102015079-102018155

Strand

Reverse strand

Band

Transcripts

ENSMUST00000094134

ENSMUSP00000091685

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042007	interleukin-18 binding

Biological Process

GO:0032496	response to lipopolysaccharide
GO:0042088	T-helper 1 type immune response
GO:0070301	cellular response to hydrogen peroxide
GO:0071356	cellular response to tumor necrosis factor

Cellular Component

GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000137496

View Gene Order

ENSBTAG00000027676

Not yet available

Cross-References

SwissProt

Q9Z0M9

TrEMBL

UniProt Splice Variant

Entrez Gene

16068

UniGene

RefSeq

NM_010531 XM_006507383

OMIM

CCDS

CCDS21522

HPRD

IMGT

MGI ID

MGI:1333800

MGI Symbol

Il18bp

EMBL

AB019505 AF110802 AF110803 AF122907 AK003370 AK008452 AK009721 AK009877 BC018332 CH466531 CT010164 CT010334

GenPept

AAD17193 AAD17194 AAD41052 AAH18332 BAA76375 BAB22744 BAB25677 BAB26462 BAB26558 CAJ18372 CAJ18542 EDL16557 EDL16558 EDL16559

RNA Seq Atlas

16068