Version 5.4
Homo sapiens Gene: IL18BP
Summary
InnateDB Gene IDBG-62960.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL18BP
Gene Name interleukin 18 binding protein
Synonyms IL18BPa
Species Homo sapiens
Ensembl Gene ENSG00000137496
Encoded Proteins
IDBP-62964
interleukin 18 binding protein
IDBP-62966
interleukin 18 binding protein
IDBP-62968
interleukin 18 binding protein
IDBP-243083
interleukin 18 binding protein
IDBP-243085
interleukin 18 binding protein
IDBP-243087
interleukin 18 binding protein
IDBP-294605
interleukin 18 binding protein
IDBP-598099
interleukin 18 binding protein
IDBP-592040
interleukin 18 binding protein
IDBP-597901
interleukin 18 binding protein
IDBP-808600
interleukin 18 binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn\'s disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:71998541-72005715
Strand Forward strand
Band q13.4
Transcripts
ENST00000343898 ENSP00000343309
ENST00000260049 ENSP00000260049
ENST00000337131 ENSP00000338723
ENST00000393707 ENSP00000377310
ENST00000393705 ENSP00000377308
ENST00000393703 ENSP00000377306
ENST00000404792 ENSP00000384212
ENST00000414358
ENST00000497194 ENSP00000434717
ENST00000525932
ENST00000531777
ENST00000531053 ENSP00000434835
ENST00000534583 ENSP00000434376
ENST00000620017 ENSP00000480621
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 3 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042007 interleukin-18 binding
GO:0048019 receptor antagonist activity
Biological Process
GO:0032496 response to lipopolysaccharide
GO:0042088 T-helper 1 type immune response
GO:0070301 cellular response to hydrogen peroxide
GO:0071356 cellular response to tumor necrosis factor
GO:1900116 extracellular negative regulation of signal transduction
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000070427
View Gene Order
ENSBTAG00000027676
Not yet available
Cross-References
SwissProt O95998
TrEMBL A0A024R5G2 Q9UNH2
UniProt Splice Variant
Entrez Gene 10068
UniGene Hs.591967
RefSeq NM_001039659 NM_001039660 NM_001145055 NM_001145057 NM_005699 NM_173042 NM_173044 XM_006718404
HUGO HGNC:5987
OMIM 604113
CCDS CCDS8206 CCDS44666
HPRD 04984
IMGT
EMBL AB019504 AF110798 AF110799 AF110800 AF110801 AF122906 AF122908 AF215907 AK098255 AP002490 BC044215 CH471076
GenPept AAD17187 AAD17188 AAD17189 AAD17190 AAD17191 AAD17192 AAD41051 AAD41053 AAF31697 AAH44215 BAA76374 BAG53602 EAW74813 EAW74816 EAW74817
RNA Seq Atlas 10068

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca