InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pdpn

Summary

InnateDB Gene

IDBG-202630.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdpn

Gene Name

podoplanin

Synonyms

Gp38; OTS-8; RANDAM-2; T1-alpha; T1a; T1alpha

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028583

Encoded Proteins

IDBP-202632

podoplanin

IDBP-400099

podoplanin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162493:
This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:143267431-143299564

Strand

Reverse strand

Band

Transcripts

ENSMUST00000030317	ENSMUSP00000030317
ENSMUST00000119654	ENSMUSP00000113776

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0000902	cell morphogenesis
GO:0001946	lymphangiogenesis
GO:0006693	prostaglandin metabolic process
GO:0006928	cellular component movement
GO:0006954	inflammatory response
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007399	nervous system development
GO:0008283	cell proliferation
GO:0008360	regulation of cell shape
GO:0009790	embryo development
GO:0010572	positive regulation of platelet activation
GO:0016337	single organismal cell-cell adhesion
GO:0030324	lung development
GO:0030335	positive regulation of cell migration
GO:0035239	tube morphogenesis
GO:0048286	lung alveolus development
GO:0051272	positive regulation of cellular component movement
GO:0055093	response to hyperoxia
GO:0061032	visceral serous pericardium development
GO:2000045	regulation of G1/S transition of mitotic cell cycle

Cellular Component

GO:0001726	ruffle
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0031258	lamellipodium membrane
GO:0031527	filopodium membrane
GO:0031528	microvillus membrane
GO:0032587	ruffle membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000162493

View Gene Order

ENSBTAG00000001788

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.2976 Mm.401392

RefSeq

NM_001290822 NM_010329 XM_006538548

OMIM

CCDS

CCDS38943 CCDS71511

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas