InnateDB Protein
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IDBP-202632.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pdpn
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Protein Name
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podoplanin
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Synonyms
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Gp38; OTS-8; RANDAM-2; T1-alpha; T1a; T1alpha;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000030317
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InnateDB Gene
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IDBG-202630 (Pdpn)
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Protein Structure
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Function |
May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels. {ECO:0000269PubMed:10574709, ECO:0000269PubMed:12032185, ECO:0000269PubMed:12654292, ECO:0000269PubMed:14522983, ECO:0000269PubMed:15231832}.
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Subcellular Localization |
Membrane {ECO:0000269PubMed:10574709}; Single-pass type I membrane protein {ECO:0000269PubMed:10574709}. Cell projection, lamellipodium membrane {ECO:0000269PubMed:10574709}; Single-pass type I membrane protein {ECO:0000269PubMed:10574709}. Cell projection, filopodium membrane {ECO:0000269PubMed:10574709}; Single-pass type I membrane protein {ECO:0000269PubMed:10574709}. Cell projection, microvillus membrane {ECO:0000269PubMed:10574709}; Single-pass type I membrane protein {ECO:0000269PubMed:10574709}. Cell projection, ruffle membrane {ECO:0000269PubMed:10574709}; Single- pass type I membrane protein {ECO:0000269PubMed:10574709}. Note=Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles.
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Disease Associations |
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Tissue Specificity |
Detected at high levels in lung and brain, at lower levels in kidney, stomach, liver, spleen and esophagus, and not detected in skin and small intestine. Expressed in epithelial cells of choroid plexus, ependyma, glomerulus and alveolus, in mesothelial cells and in endothelia of lymphatic vessels. Also expressed in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. Detected in carcinoma cell lines and cultured fibroblasts. Expressed at higher levels in colon carcinomas than in normal colon tissue. {ECO:0000269PubMed:10574709, ECO:0000269PubMed:12032185, ECO:0000269PubMed:14522983}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:103098
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InterPro |
IPR008783
Podoplanin
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PFAM |
PF05808
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q62011
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
14726
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UniGene |
Mm.401392
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RefSeq |
NP_034459
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MGI ID |
3IET
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MGI Symbol |
Pdpn
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OMIM |
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CCDS |
CCDS38943
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HPRD |
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IMGT |
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EMBL |
AJ250246
AJ297944
AK158855
AL611982
AY115493
BC026551
M73748
M96645
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GenPept |
AAA37724
AAA39866
AAH26551
AAM66761
BAE34695
CAB58997
CAC16152
CAM21724
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