InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rhog

Summary

InnateDB Gene

IDBG-202752.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rhog

Gene Name

ras homolog gene family, member G

Synonyms

2810426G09Rik; Arhg; Sid10750

Species

Mus musculus

Ensembl Gene

ENSMUSG00000073982

Encoded Proteins

IDBP-202754

ras homolog gene family, member G

IDBP-267760

ras homolog gene family, member G

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177105:
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:102239123-102250123

Strand

Reverse strand

Band

Transcripts

ENSMUST00000098230	ENSMUSP00000095832
ENSMUST00000106923	ENSMUSP00000102536

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007266	Rho protein signal transduction
GO:0015031	protein transport
GO:0016601	Rac protein signal transduction
GO:0030036	actin cytoskeleton organization
GO:0032863	activation of Rac GTPase activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060326	cell chemotaxis
GO:0090004	positive regulation of establishment of protein localization to plasma membrane
GO:1900027	regulation of ruffle assembly