InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RHOG

Summary

InnateDB Gene

IDBG-24680.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RHOG

Gene Name

ras homolog family member G

Synonyms

ARHG

Species

Homo sapiens

Ensembl Gene

ENSG00000177105

Encoded Proteins

IDBP-24682

ras homolog gene family, member G (rho G)

IDBP-236355

ras homolog gene family, member G (rho G)

IDBP-236357

ras homolog gene family, member G (rho G)

IDBP-591953

ras homolog gene family, member G (rho G)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:3826978-3840983

Strand

Reverse strand

Band

p15.4

Transcripts

ENST00000351018	ENSP00000339467
ENST00000396979	ENSP00000380176
ENST00000396978	ENSP00000380175
ENST00000533217	ENSP00000436932

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007266	Rho protein signal transduction
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0015031	protein transport
GO:0016601	Rac protein signal transduction
GO:0030036	actin cytoskeleton organization
GO:0030168	platelet activation
GO:0032863	activation of Rac GTPase activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0060326	cell chemotaxis
GO:0090004	positive regulation of establishment of protein localization to plasma membrane
GO:1900027	regulation of ruffle assembly