InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Stim1

Summary

InnateDB Gene

IDBG-202769.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stim1

Gene Name

stromal interaction molecule 1

Synonyms

SIM

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030987

Encoded Proteins

IDBP-202771

stromal interaction molecule 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21239714

Stim1 supports the influx of extracellular Ca(2+), which is required for production of reactive oxygen species in phagocytosis.

InnateDB Annotation from Orthologs

Summary

PMID 21239714

[Homo sapiens] STIM1 supports the influx of extracellular Ca(2+), which is required for production of reactive oxygen species in phagocytosis.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167323:
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene.[provided by RefSeq, Jan 2009]
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3\' end of this gene situated 1.6 kb from the 5\' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:102267824-102436848

Strand

Forward strand

Band

Transcripts

ENSMUST00000033289

ENSMUSP00000033289

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005246	calcium channel regulator activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0015279	store-operated calcium channel activity
GO:0042802	identical protein binding
GO:0051010	microtubule plus-end binding

Biological Process

GO:0002115	store-operated calcium entry
GO:0005513	detection of calcium ion
GO:0006812	cation transport
GO:0032237	activation of store-operated calcium channel activity
GO:0045087	innate immune response (InnateDB)
GO:0051924	regulation of calcium ion transport
GO:0070588	calcium ion transmembrane transport
GO:2001256	regulation of store-operated calcium entry

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0030426	growth cone
GO:0032541	cortical endoplasmic reticulum
GO:0043234	protein complex