InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Stim1

Summary

InnateDB Protein

IDBP-202771.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stim1

Protein Name

stromal interaction molecule 1

Synonyms

SIM;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033289

InnateDB Gene

IDBG-202769 (Stim1)

Protein Structure

UniProt Annotation

Function

Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1 (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular Ca(2+) and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane. Associated with the microtubule network at the growing distal tip of microtubules (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in all tissues examined and in many cell types, including bone marrow stroma, fibroblast, B-cell precursors, lymphoma and erythroleukemia. {ECO:0000269PubMed:8707854}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005246	calcium channel regulator activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0015279	store-operated calcium channel activity
GO:0042802	identical protein binding
GO:0051010	microtubule plus-end binding

Biological Process

GO:0002115	store-operated calcium entry
GO:0005513	detection of calcium ion
GO:0006812	cation transport
GO:0032237	activation of store-operated calcium channel activity
GO:0045087	innate immune response (InnateDB)
GO:0051924	regulation of calcium ion transport
GO:0070588	calcium ion transmembrane transport
GO:2001256	regulation of store-operated calcium entry

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0030426	growth cone
GO:0032541	cortical endoplasmic reticulum
GO:0043234	protein complex