Version 5.4
Mus musculus Gene: Duox2
Summary
InnateDB Gene IDBG-202825.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Duox2
Gene Name dual oxidase 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000068452
Encoded Proteins
IDBP-202827
dual oxidase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21714724
Duox2 plays pivotal roles in the Tlr5-dependent inflammatory response of nasal airway epithelium. Duox2 activation is required for flagellin-induced reactive oxygen species production, as well as the induction of mucin and MIP-2alpha in nasal epithelial cells.
InnateDB Annotation from Orthologs
Summary
PMID 19759286
[Homo sapiens] DUOX2 is a member of the NAD(P)H oxidase family and is involved in NOD2-dependent reactive oxygen species (ROS) production.
PMID 18511861
[Homo sapiens] DUOX2 and DUOX1 localize to the apical plasma membrane of epithelial cells in major airways, salivary glands, and the gastrointestinal tract, and provide extracellular hydrogen peroxide to lactoperoxidase to produce antimicrobial hypothiocyanite ions. Expression of dual oxidases DUOX2 and DUOX1 is regulated by Th1 and Th2 cytokines in human airways.
PMID 20381453
[Homo sapiens] DUOX2 expression is mediated by IFN-gamma via a STAT-independent signalling pathway, providing insights into a novel IFN-gamma signalling pathway with potential importance for regulation of host defence responses.
PMID 21714724
[Homo sapiens] DUOX2 plays pivotal roles in the TLR5-dependent inflammatory response of nasal airway epithelium. DUOX2 activation is required for flagellin-induced reactive oxygen species production, as well as the induction of mucin and MIP-2alpha in nasal epithelial cells.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140279:
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:122279247-122298165
Strand Reverse strand
Band E5
Transcripts
ENSMUST00000053734 ENSMUSP00000050314
ENSMUST00000155820
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004601 peroxidase activity
GO:0005509 calcium ion binding
GO:0016174 NAD(P)H oxidase activity
GO:0016491 oxidoreductase activity
GO:0020037 heme binding
Biological Process
GO:0006979 response to oxidative stress
GO:0009566 fertilization
GO:0009615 response to virus
GO:0030282 bone mineralization
GO:0030878 thyroid gland development
GO:0035264 multicellular organism growth
GO:0042403 thyroid hormone metabolic process
GO:0042445 hormone metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0048839 inner ear development
GO:0048855 adenohypophysis morphogenesis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000140279
View Gene Order
ENSBTAG00000016234
Not yet available
Cross-References
SwissProt
TrEMBL A2AQ99
UniProt Splice Variant
Entrez Gene 214593
UniGene
RefSeq NM_177610
OMIM
CCDS CCDS38221
HPRD
IMGT
MGI ID MGI:3036280
MGI Symbol Duox2
EMBL AL844566
GenPept
RNA Seq Atlas 214593

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca