InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Duox2

Summary

InnateDB Protein

IDBP-202827.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Duox2

Protein Name

dual oxidase 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050314

InnateDB Gene

IDBG-202825 (Duox2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004601	peroxidase activity
GO:0005509	calcium ion binding
GO:0016174	NAD(P)H oxidase activity
GO:0016491	oxidoreductase activity
GO:0020037	heme binding

Biological Process

GO:0006979	response to oxidative stress
GO:0009566	fertilization
GO:0009615	response to virus
GO:0030282	bone mineralization
GO:0030878	thyroid gland development
GO:0035264	multicellular organism growth
GO:0042403	thyroid hormone metabolic process
GO:0042445	hormone metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0048839	inner ear development
GO:0048855	adenohypophysis morphogenesis
GO:0055114	oxidation-reduction process

Cellular Component

GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:3036280

InterPro

IPR002007 Haem peroxidase, animal
IPR002048 EF-hand domain
IPR010255 Haem peroxidase
IPR013112 FAD-binding 8
IPR013121 Ferric reductase, NAD binding
IPR013130 Ferric reductase transmembrane component-like domain
IPR017938 Riboflavin synthase-like beta-barrel
IPR019791 Haem peroxidase, animal, subgroup

PFAM