Version 5.4
Mus musculus Gene: Dclk3
Summary
InnateDB Gene IDBG-202865.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dclk3
Gene Name doublecortin-like kinase 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000032500
Encoded Proteins
IDBP-257193
doublecortin-like kinase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the protein kinase superfamily and the doublecortin family. Differently from the other two closely related family members (DCLK1 and DCLK2), the protein encoded by this gene contains only one N-terminal doublecortin domain and is unable to bind microtubules and to regulate microtubule polymerization. The protein contains a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:111439081-111489608
Strand Forward strand
Band F3
Transcripts
ENSMUST00000111879 ENSMUSP00000107510
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000163673
View Gene Order
ENSBTAG00000039727
Not yet available
Cross-References
SwissProt Q8BWQ5
TrEMBL
UniProt Splice Variant
Entrez Gene 245038
UniGene Mm.26361
RefSeq NM_172928
OMIM
CCDS CCDS23585
HPRD
IMGT
MGI ID MGI:3039580
MGI Symbol Dclk3
EMBL AK050312 BC056929 DQ286388
GenPept AAH56929 ABB89470 BAC34182
RNA Seq Atlas 245038

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca