Version 5.4
Mus musculus Gene: Tnfaip1
Summary
InnateDB Gene IDBG-203000.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tnfaip1
Gene Name tumor necrosis factor, alpha-induced protein 1 (endothelial)
Synonyms Edp-1; Edp1; Tnfip1
Species Mus musculus
Ensembl Gene ENSMUSG00000017615
Encoded Proteins
IDBP-203002
tumor necrosis factor, alpha-induced protein 1 (endothelial)
IDBP-264876
tumor necrosis factor, alpha-induced protein 1 (endothelial)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109079:
This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:78522850-78536332
Strand Reverse strand
Band B5
Transcripts
ENSMUST00000017759 ENSMUSP00000017759
ENSMUST00000108277 ENSMUSP00000103912
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0017049 GTP-Rho binding
GO:0019904 protein domain specific binding
Biological Process
GO:0006260 DNA replication
GO:0006955 immune response
GO:0009790 embryo development
GO:0016477 cell migration
GO:0016567 protein ubiquitination
GO:0035024 negative regulation of Rho protein signal transduction
GO:0043149 stress fiber assembly
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045740 positive regulation of DNA replication
GO:0051260 protein homooligomerization
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0031463 Cul3-RING ubiquitin ligase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000109079
View Gene Order
ENSBTAG00000008115
Not yet available
Cross-References
SwissProt O70479
TrEMBL
UniProt Splice Variant
Entrez Gene 21927
UniGene Mm.386774 Mm.397036 Mm.473397
RefSeq NM_001159392 NM_009395
OMIM
CCDS CCDS25110
HPRD
IMGT
MGI ID MGI:104961
MGI Symbol Tnfaip1
EMBL AF061341 AF061342 AF061343 AF061344 AF061345 AF061346 AK004593 AK034305 AK079869 AK147809 AK168386 AK168704 AL591177 BC003906
GenPept AAC78826 AAH03906 BAB23395 BAC28668 BAC37770 BAE28152 BAE40313 BAE40546 CAI25552
RNA Seq Atlas 21927

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca