InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Limk1

Summary

InnateDB Gene

IDBG-203064.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Limk1

Gene Name

LIM-domain containing, protein kinase

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029674

Encoded Proteins

IDBP-203068

LIM-domain containing, protein kinase

IDBP-258560

LIM-domain containing, protein kinase

IDBP-541819

LIM-domain containing, protein kinase

IDBP-538955

LIM-domain containing, protein kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106683:
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:134656039-134688590

Strand

Reverse strand

Band

Transcripts

ENSMUST00000015137	ENSMUSP00000015137
ENSMUST00000111233	ENSMUSP00000106864
ENSMUST00000134093	ENSMUSP00000121718
ENSMUST00000138590	ENSMUSP00000118268
ENSMUST00000137897
ENSMUST00000132027

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0031072	heat shock protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006468	protein phosphorylation
GO:0009103	lipopolysaccharide biosynthetic process
GO:0032233	positive regulation of actin filament bundle assembly
GO:0045773	positive regulation of axon extension
GO:0051444	negative regulation of ubiquitin-protein transferase activity
GO:0051496	positive regulation of stress fiber assembly