InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cldn4

Summary

InnateDB Gene

IDBG-203317.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cldn4

Gene Name

claudin 4

Synonyms

Cep-r; Cpetr; Cpetr1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000047501

Encoded Proteins

IDBP-203319

claudin 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a high-affinity receptor for clostridium perfringens enterotoxin (CPE) produced by the bacterium Clostridium perfringens, and the interaction with CPE results in increased membrane permeability by forming small pores in plasma membrane. This protein augments alveolar epithelial barrier function and is induced in acute lung injury. It is highly expressed in pancreatic and ovarian cancers. [provided by RefSeq, Aug 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:134945126-134946934

Strand

Reverse strand

Band

Transcripts

ENSMUST00000051401

ENSMUSP00000053420

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0007565	female pregnancy
GO:0016338	calcium-independent cell-cell adhesion
GO:0032570	response to progesterone
GO:0061436	establishment of skin barrier

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005923	tight junction
GO:0009925	basal plasma membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0016327	apicolateral plasma membrane
GO:0016328	lateral plasma membrane