InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cldn4

Summary

InnateDB Protein

IDBP-203319.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cldn4

Protein Name

claudin 4

Synonyms

Cep-r; Cpetr; Cpetr1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000053420

InnateDB Gene

IDBG-203317 (Cldn4)

Protein Structure

UniProt Annotation

Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. {ECO:0000250}.

Subcellular Localization

Cell junction, tight junction {ECO:0000269PubMed:9892664}. Cell membrane {ECO:0000269PubMed:9892664}; Multi-pass membrane protein {ECO:0000269PubMed:9892664}.

Disease Associations

Tissue Specificity

Expressed primarily in lung and kidney. {ECO:0000269PubMed:9892664}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0007565	female pregnancy
GO:0016338	calcium-independent cell-cell adhesion
GO:0032570	response to progesterone
GO:0061436	establishment of skin barrier

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005923	tight junction
GO:0009925	basal plasma membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0016327	apicolateral plasma membrane
GO:0016328	lateral plasma membrane