InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lmx1a

Summary

InnateDB Gene

IDBG-203344.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lmx1a

Gene Name

LIM homeobox transcription factor 1 alpha

Synonyms

dr; dreher; Lmx1.1; sst

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026686

Encoded Proteins

IDBP-203346

LIM homeobox transcription factor 1 alpha

IDBP-258277

LIM homeobox transcription factor 1 alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162761:
This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development of dopamine producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk of developing Parkinson's disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development of dopamine producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk of developing Parkinson\'s disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:167689237-167848741

Strand

Forward strand

Band

H2.3

Transcripts

ENSMUST00000028003	ENSMUSP00000028003
ENSMUST00000111377	ENSMUSP00000107008

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001558	regulation of cell growth
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007411	axon guidance
GO:0007417	central nervous system development
GO:0007420	brain development
GO:0010468	regulation of gene expression
GO:0021542	dentate gyrus development
GO:0021549	cerebellum development
GO:0021766	hippocampus development
GO:0021953	central nervous system neuron differentiation
GO:0030182	neuron differentiation
GO:0030901	midbrain development
GO:0045665	negative regulation of neuron differentiation
GO:0071542	dopaminergic neuron differentiation

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000162761

View Gene Order

ENSBTAG00000012025

Not yet available

Cross-References

SwissProt

Q9JKU8

TrEMBL

Q543W2

UniProt Splice Variant

Entrez Gene

110648

UniGene

Mm.330081

RefSeq

NM_033652 XM_006496611 XM_006496612

OMIM

CCDS

CCDS15460

HPRD

IMGT

MGI ID

MGI:1888519

MGI Symbol

Lmx1a

EMBL

AF226662 AK044944 BC109167 BC109168

GenPept

AAF43012 AAI09168 AAI09169 BAC32153

RNA Seq Atlas

110648