InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lmx1a

Summary

InnateDB Protein

IDBP-203346.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lmx1a

Protein Name

LIM homeobox transcription factor 1 alpha

Synonyms

dr; dreher; Lmx1.1; sst;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028003

InnateDB Gene

IDBG-203344 (Lmx1a)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.

Disease Associations

Note=Defects in Lmx1a are the cause of the spontaneous neurologic mutant mouse, called 'dreher' (dr) and results from a failure of the roof plate to develop.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001558	regulation of cell growth
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007411	axon guidance
GO:0007417	central nervous system development
GO:0007420	brain development
GO:0010468	regulation of gene expression
GO:0021542	dentate gyrus development
GO:0021549	cerebellum development
GO:0021766	hippocampus development
GO:0021953	central nervous system neuron differentiation
GO:0030182	neuron differentiation
GO:0030901	midbrain development
GO:0045665	negative regulation of neuron differentiation
GO:0071542	dopaminergic neuron differentiation