InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hbb-y

Summary

InnateDB Gene

IDBG-203771.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hbb-y

Gene Name

hemoglobin Y, beta-like embryonic chain

Synonyms

Ey; Hby

Species

Mus musculus

Ensembl Gene

ENSMUSG00000052187

Encoded Proteins

IDBP-203773

hemoglobin Y, beta-like embryonic chain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213931:
The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon - G-gamma - A-gamma - delta - beta-3' [provided by RefSeq, Jul 2008]
The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5\'-epsilon - G-gamma - A-gamma - delta - beta-3\' [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:103851745-103853240

Strand

Reverse strand

Band

Transcripts

ENSMUST00000033229

ENSMUSP00000033229

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005344	oxygen transporter activity
GO:0005506	iron ion binding
GO:0019825	oxygen binding
GO:0020037	heme binding
GO:0031721	hemoglobin alpha binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0015671	oxygen transport
GO:0051291	protein heterooligomerization

Cellular Component

GO:0005833	hemoglobin complex
GO:0072562	blood microparticle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000213931

View Gene Order

ENSBTAG00000037815

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_24970

Factors involved in megakaryocyte development and platelet production pathway

REACT_604

Hemostasis pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

Q9CR49

UniProt Splice Variant

Entrez Gene

15135

UniGene

Mm.467549 Mm.467553

RefSeq

NM_008221

OMIM

CCDS

CCDS21593

HPRD

IMGT

MGI ID

MGI:96027

MGI Symbol

Hbb-y

EMBL

AC131116 AK012501 AK012897 BC057014

GenPept

AAH57014 BAB28284 BAB28541

RNA Seq Atlas

15135