Version 5.4
Mus musculus Gene: Nppb
Summary
InnateDB Gene IDBG-203956.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nppb
Gene Name natriuretic peptide type B
Synonyms AA408272; BNF; BNP
Species Mus musculus
Ensembl Gene ENSMUSG00000029019
Encoded Proteins
IDBP-203958
natriuretic peptide type B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a secreted protein that belongs to the family of natriuretic peptides. Its precursor protein is processed to generate the active mature peptide. The mature peptide is a cardiac hormone that plays a role in ventricular remodeling as well as blood pressure regulation. Mice lacking this gene exhibit cardiac fibrosis. In humans this gene is associated with congestive heart failure, low bone-mineral density and postmenopausal osteoporosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:147985788-147987205
Strand Forward strand
Band E2
Transcripts
ENSMUST00000103231 ENSMUSP00000099521
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0051428 peptide hormone receptor binding
Biological Process
GO:0001666 response to hypoxia
GO:0003085 negative regulation of systemic arterial blood pressure
GO:0006182 cGMP biosynthetic process
GO:0006954 inflammatory response
GO:0007168 receptor guanylyl cyclase signaling pathway
GO:0007507 heart development
GO:0008217 regulation of blood pressure
GO:0014070 response to organic cyclic compound
GO:0030308 negative regulation of cell growth
GO:0032496 response to lipopolysaccharide
GO:0035810 positive regulation of urine volume
GO:0035815 positive regulation of renal sodium excretion
GO:0042493 response to drug
GO:0043434 response to peptide hormone
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050880 regulation of blood vessel size
GO:0051592 response to calcium ion
GO:0071260 cellular response to mechanical stimulus
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0043234 protein complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
No orthologs found for this gene
Cross-References
SwissProt P40753
TrEMBL Q54AE9
UniProt Splice Variant
Entrez Gene 18158
UniGene Mm.2740
RefSeq NM_001287348 NM_008726
OMIM
CCDS CCDS18926
HPRD
IMGT
MGI ID MGI:97368
MGI Symbol Nppb
EMBL AB039044 AB039047 AB039052 AK003128 BC061165 D16497 S58667
GenPept AAB26344 AAH61165 BAA03948 BAB22588 BAB68568 BAB68571 BAB68576
RNA Seq Atlas 18158

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca