InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nppb

Summary

InnateDB Protein

IDBP-203958.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nppb

Protein Name

natriuretic peptide type B

Synonyms

AA408272; BNF; BNP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099521

InnateDB Gene

IDBG-203956 (Nppb)

Protein Structure

UniProt Annotation

Function

Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed abundantly in the ventricle, and in a lesser extent in the atrium.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0051428	peptide hormone receptor binding

Biological Process

GO:0001666	response to hypoxia
GO:0003085	negative regulation of systemic arterial blood pressure
GO:0006182	cGMP biosynthetic process
GO:0006954	inflammatory response
GO:0007168	receptor guanylyl cyclase signaling pathway
GO:0007507	heart development
GO:0008217	regulation of blood pressure
GO:0014070	response to organic cyclic compound
GO:0030308	negative regulation of cell growth
GO:0032496	response to lipopolysaccharide
GO:0035810	positive regulation of urine volume
GO:0035815	positive regulation of renal sodium excretion
GO:0042493	response to drug
GO:0043434	response to peptide hormone
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0050880	regulation of blood vessel size
GO:0051592	response to calcium ion
GO:0071260	cellular response to mechanical stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm