Version 5.4
Mus musculus Gene: Por
Summary
InnateDB Gene IDBG-204005.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Por
Gene Name P450 (cytochrome) oxidoreductase
Synonyms 4933424M13Rik; CPR; CYPOR
Species Mus musculus
Ensembl Gene ENSMUSG00000005514
Encoded Proteins
IDBP-204007
P450 (cytochrome) oxidoreductase
IDBP-400169
P450 (cytochrome) oxidoreductase
IDBP-536166
P450 (cytochrome) oxidoreductase
IDBP-538815
P450 (cytochrome) oxidoreductase
IDBP-537773
P450 (cytochrome) oxidoreductase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127948:
This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:135670033-135735326
Strand Forward strand
Band G2
Transcripts
ENSMUST00000005651 ENSMUSP00000005651
ENSMUST00000122113 ENSMUSP00000112924
ENSMUST00000153500 ENSMUSP00000121531
ENSMUST00000150058
ENSMUST00000153515 ENSMUSP00000121022
ENSMUST00000147515
ENSMUST00000127096 ENSMUSP00000119138
ENSMUST00000149684
ENSMUST00000132084
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003958 NADPH-hemoprotein reductase activity
GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0008941 nitric oxide dioxygenase activity
GO:0009055 electron carrier activity
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0016787 hydrolase activity
GO:0019899 enzyme binding
GO:0047726 iron-cytochrome-c reductase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0003420 regulation of growth plate cartilage chondrocyte proliferation
GO:0007584 response to nutrient
GO:0009437 carnitine metabolic process
GO:0009812 flavonoid metabolic process
GO:0018393 internal peptidyl-lysine acetylation
GO:0019395 fatty acid oxidation
GO:0032332 positive regulation of chondrocyte differentiation
GO:0032770 positive regulation of monooxygenase activity
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043602 nitrate catabolic process
GO:0045542 positive regulation of cholesterol biosynthetic process
GO:0045880 positive regulation of smoothened signaling pathway
GO:0046210 nitric oxide catabolic process
GO:0055114 oxidation-reduction process
GO:0060192 negative regulation of lipase activity
GO:0070988 demethylation
GO:0071371 cellular response to gonadotropin stimulus
GO:0071372 cellular response to follicle-stimulating hormone stimulus
GO:0071375 cellular response to peptide hormone stimulus
GO:0090031 positive regulation of steroid hormone biosynthetic process
GO:0090181 regulation of cholesterol metabolic process
GO:0090346 cellular organofluorine metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000127948
View Gene Order
ENSBTAG00000017082
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.3863 Mm.413112 Mm.488967
RefSeq NM_008898 XM_006504398 XM_006504399
OMIM
CCDS CCDS39318
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca