InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sdhc

Summary

InnateDB Gene

IDBG-204104.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sdhc

Gene Name

succinate dehydrogenase complex, subunit C, integral membrane protein

Synonyms

0610010E03Rik; AI316496; AU019277

Species

Mus musculus

Ensembl Gene

ENSMUSG00000058076

Encoded Proteins

IDBP-204106

succinate dehydrogenase complex, subunit C, integral membrane protein

IDBP-258352

succinate dehydrogenase complex, subunit C, integral membrane protein

IDBP-532669

succinate dehydrogenase complex, subunit C, integral membrane protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143252:
This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. Several related pseudogenes are located in different genomic regions. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:171127165-171150603

Strand

Reverse strand

Band

Transcripts

ENSMUST00000081560	ENSMUSP00000080273
ENSMUST00000111336	ENSMUSP00000106968
ENSMUST00000155798	ENSMUSP00000122062

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000104	succinate dehydrogenase activity
GO:0009055	electron carrier activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0020037	heme binding
GO:0046872	metal ion binding

Biological Process

GO:0006099

tricarboxylic acid cycle

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005749	mitochondrial respiratory chain complex II
GO:0016021	integral component of membrane
GO:0045281	succinate dehydrogenase complex