InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sdhc

Summary

InnateDB Protein

IDBP-258352.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sdhc

Protein Name

succinate dehydrogenase complex, subunit C, integral membrane protein

Synonyms

0610010E03Rik; AI316496; AU019277;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106968

InnateDB Gene

IDBG-204104 (Sdhc)

Protein Structure

UniProt Annotation

Function

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). {ECO:0000250}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000104	succinate dehydrogenase activity
GO:0009055	electron carrier activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0020037	heme binding
GO:0046872	metal ion binding

Biological Process

GO:0006099

tricarboxylic acid cycle

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005749	mitochondrial respiratory chain complex II
GO:0016021	integral component of membrane
GO:0045281	succinate dehydrogenase complex

Protein Structure and Domains

PDB ID

MGI:1913302

InterPro

IPR000701 Succinate dehydrogenase/Fumarate reductase, transmembrane subunit
IPR014314 Succinate dehydrogenase, cytochrome b556 subunit
IPR014361 Succinate dehydrogenase, cytochrome b560 subunit

PFAM

PF01127

PRINTS

PIRSF

PIRSF000178

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CZB0