Version 5.4
Mus musculus Gene: Trim30a
Summary
InnateDB Gene IDBG-204202.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trim30a
Gene Name tripartite motif-containing 30A
Synonyms Rpt-1; Rpt1; Trim30
Species Mus musculus
Ensembl Gene ENSMUSG00000030921
Encoded Proteins
IDBP-204204
tripartite motif-containing 30A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18345001
Trim30 negatively regulates TLR mediated NF-kappaB activation by targeting Map3k7ip2 (TAB2) and Map3k7ip3 (TAB3) for degradation.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 7:104409025-104465193
Strand Reverse strand
Band E3
Transcripts
ENSMUST00000076922 ENSMUSP00000076189
ENSMUST00000152397
ENSMUST00000125762
ENSMUST00000142124
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0045732 positive regulation of protein catabolic process
GO:0046598 positive regulation of viral entry into host cell
GO:0051865 protein autoubiquitination
GO:1900226 negative regulation of NLRP3 inflammasome complex assembly
GO:2000378 negative regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.413306
RefSeq NM_009099 XM_006507471
OMIM
CCDS CCDS40068
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca