InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trim30a

Summary

InnateDB Protein

IDBP-204204.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim30a

Protein Name

tripartite motif-containing 30A

Synonyms

Rpt-1; Rpt1; Trim30;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000076189

InnateDB Gene

IDBG-204202 (Trim30a)

Protein Structure

UniProt Annotation

Function

Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain. May affect IL2R-alpha expression through cis-acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences. Negatively regulates Toll-like receptor (TLR)-mediated activation of NFKB by promoting degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination. Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex. This, in turn, regulates activation of CASP1 and subsequent cleavage of IL1B and IL18. No activity detected against a range of retroviruses including a number of lentiviruses, gammaretroviruses and betaretroviruses. {ECO:0000269PubMed:18345001, ECO:0000269PubMed:19147168, ECO:0000269PubMed:21048113}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Highly expressed in spleen and lymph nodes (at protein level). {ECO:0000269PubMed:18345001}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0032715	negative regulation of interleukin-6 production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0034122	negative regulation of toll-like receptor signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045732	positive regulation of protein catabolic process
GO:0046598	positive regulation of viral entry into host cell
GO:0051865	protein autoubiquitination
GO:1900226	negative regulation of NLRP3 inflammasome complex assembly
GO:2000378	negative regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:98178

InterPro

IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003877 SPla/RYanodine receptor SPRY
IPR003879 Butyrophylin-like
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018355 SPla/RYanodine receptor subgroup
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF00643
PF13639
PF14634
PF00622
PF00097

PRINTS

PR01407

PIRSF

SMART

SM00336
SM00184
SM00449

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt