Version 5.4
Mus musculus Gene: Ccl2
Summary
InnateDB Gene IDBG-204473.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ccl2
Gene Name chemokine (C-C motif) ligand 2
Synonyms AI323594; HC11; JE; MCAF; MCP-1; MCP1; Scya2; Sigje; SMC-CF
Species Mus musculus
Ensembl Gene ENSMUSG00000035385
Encoded Proteins
IDBP-204475
chemokine (C-C motif) ligand 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21458307
Ccl2 is secreted by bone marrow mesenchymal stem cells in response to circulating TLR ligands or bacterial infection, which then induces monocyte trafficking into the bloodstream.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 11:82035571-82037453
Strand Forward strand
Band C
Transcripts
ENSMUST00000000193 ENSMUSP00000000193
ENSMUST00000124479
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 7 [view]
Protein-DNA 12 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0005515 protein binding
GO:0008009 chemokine activity
GO:0008201 heparin binding
GO:0031727 CCR2 chemokine receptor binding
Biological Process
GO:0000165 MAPK cascade
GO:0001525 angiogenesis
GO:0001666 response to hypoxia
GO:0001912 positive regulation of leukocyte mediated cytotoxicity
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002523 leukocyte migration involved in inflammatory response
GO:0002548 monocyte chemotaxis
GO:0002687 positive regulation of leukocyte migration
GO:0002693 positive regulation of cellular extravasation
GO:0006874 cellular calcium ion homeostasis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007010 cytoskeleton organization
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007568 aging
GO:0008347 glial cell migration
GO:0008360 regulation of cell shape
GO:0009408 response to heat
GO:0009611 response to wounding
GO:0009612 response to mechanical stimulus
GO:0009617 response to bacterium
GO:0010332 response to gamma radiation
GO:0010574 regulation of vascular endothelial growth factor production
GO:0010759 positive regulation of macrophage chemotaxis
GO:0014823 response to activity
GO:0016525 negative regulation of angiogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0022409 positive regulation of cell-cell adhesion
GO:0030593 neutrophil chemotaxis
GO:0031100 organ regeneration
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0032570 response to progesterone
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032869 cellular response to insulin stimulus
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033552 response to vitamin B3
GO:0034351 negative regulation of glial cell apoptotic process
GO:0035684 helper T cell extravasation
GO:0035690 cellular response to drug
GO:0035702 monocyte homeostasis
GO:0036006 cellular response to macrophage colony-stimulating factor stimulus
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0042493 response to drug
GO:0043200 response to amino acid
GO:0043491 protein kinase B signaling
GO:0043524 negative regulation of neuron apoptotic process
GO:0043615 astrocyte cell migration
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0045087 innate immune response (InnateDB)
GO:0045471 response to ethanol
GO:0045785 positive regulation of cell adhesion
GO:0046677 response to antibiotic
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048246 macrophage chemotaxis
GO:0048247 lymphocyte chemotaxis
GO:0050806 positive regulation of synaptic transmission
GO:0050870 positive regulation of T cell activation
GO:0051384 response to glucocorticoid
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0060135 maternal process involved in female pregnancy
GO:0060137 maternal process involved in parturition
GO:0070098 chemokine-mediated signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:0071300 cellular response to retinoic acid
GO:0071318 cellular response to ATP
GO:0071346 cellular response to interferon-gamma
GO:0071347 cellular response to interleukin-1
GO:0071354 cellular response to interleukin-6
GO:0071356 cellular response to tumor necrosis factor
GO:0071402 cellular response to lipoprotein particle stimulus
GO:0071403 cellular response to high density lipoprotein particle stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071549 cellular response to dexamethasone stimulus
GO:0090026 positive regulation of monocyte chemotaxis
GO:0090265 positive regulation of immune complex clearance by monocytes and macrophages
GO:0090280 positive regulation of calcium ion import
GO:2000427 positive regulation of apoptotic cell clearance
GO:2000502 negative regulation of natural killer cell chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005791 rough endoplasmic reticulum
GO:0030139 endocytic vesicle
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0043204 perikaryon
GO:0043679 axon terminus
GO:0044299 C-fiber
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04062
Chemokine signaling pathway pathway
mmu04621
NOD-like receptor signaling pathway pathway
mmu05144
Malaria pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.413131
RefSeq NM_011333
OMIM
CCDS CCDS25139
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca