InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccl2

Summary

InnateDB Protein

IDBP-204475.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccl2

Protein Name

chemokine (C-C motif) ligand 2

Synonyms

AI323594; HC11; JE; MCAF; MCP-1; MCP1; Scya2; Sigje; SMC-CF;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000193

InnateDB Gene

IDBG-204473 (Ccl2)

Protein Structure

UniProt Annotation

Function

Chemotactic factor that attracts monocytes, but not neutrophils.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	7 [view]
Protein-DNA	12 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0005515	protein binding
GO:0008009	chemokine activity
GO:0008201	heparin binding
GO:0031727	CCR2 chemokine receptor binding

Biological Process

GO:0000165	MAPK cascade
GO:0001525	angiogenesis
GO:0001666	response to hypoxia
GO:0001912	positive regulation of leukocyte mediated cytotoxicity
GO:0001938	positive regulation of endothelial cell proliferation
GO:0002523	leukocyte migration involved in inflammatory response
GO:0002548	monocyte chemotaxis
GO:0002687	positive regulation of leukocyte migration
GO:0002693	positive regulation of cellular extravasation
GO:0006874	cellular calcium ion homeostasis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007010	cytoskeleton organization
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007568	aging
GO:0008347	glial cell migration
GO:0008360	regulation of cell shape
GO:0009408	response to heat
GO:0009611	response to wounding
GO:0009612	response to mechanical stimulus
GO:0009617	response to bacterium
GO:0010332	response to gamma radiation
GO:0010574	regulation of vascular endothelial growth factor production
GO:0010759	positive regulation of macrophage chemotaxis
GO:0014823	response to activity
GO:0016525	negative regulation of angiogenesis
GO:0019221	cytokine-mediated signaling pathway
GO:0022409	positive regulation of cell-cell adhesion
GO:0030593	neutrophil chemotaxis
GO:0031100	organ regeneration
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032496	response to lipopolysaccharide
GO:0032570	response to progesterone
GO:0032760	positive regulation of tumor necrosis factor production
GO:0032869	cellular response to insulin stimulus
GO:0032967	positive regulation of collagen biosynthetic process
GO:0033552	response to vitamin B3
GO:0034351	negative regulation of glial cell apoptotic process
GO:0035684	helper T cell extravasation
GO:0035690	cellular response to drug
GO:0035702	monocyte homeostasis
GO:0036006	cellular response to macrophage colony-stimulating factor stimulus
GO:0036120	cellular response to platelet-derived growth factor stimulus
GO:0042493	response to drug
GO:0043200	response to amino acid
GO:0043491	protein kinase B signaling
GO:0043524	negative regulation of neuron apoptotic process
GO:0043615	astrocyte cell migration
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0045087	innate immune response (InnateDB)
GO:0045471	response to ethanol
GO:0045785	positive regulation of cell adhesion
GO:0046677	response to antibiotic
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048246	macrophage chemotaxis
GO:0048247	lymphocyte chemotaxis
GO:0050806	positive regulation of synaptic transmission
GO:0050870	positive regulation of T cell activation
GO:0051384	response to glucocorticoid
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process
GO:0060135	maternal process involved in female pregnancy
GO:0060137	maternal process involved in parturition
GO:0070098	chemokine-mediated signaling pathway
GO:0071222	cellular response to lipopolysaccharide
GO:0071300	cellular response to retinoic acid
GO:0071318	cellular response to ATP
GO:0071346	cellular response to interferon-gamma
GO:0071347	cellular response to interleukin-1
GO:0071354	cellular response to interleukin-6
GO:0071356	cellular response to tumor necrosis factor
GO:0071402	cellular response to lipoprotein particle stimulus
GO:0071403	cellular response to high density lipoprotein particle stimulus
GO:0071407	cellular response to organic cyclic compound
GO:0071549	cellular response to dexamethasone stimulus
GO:0090026	positive regulation of monocyte chemotaxis
GO:0090265	positive regulation of immune complex clearance by monocytes and macrophages
GO:0090280	positive regulation of calcium ion import
GO:2000427	positive regulation of apoptotic cell clearance
GO:2000502	negative regulation of natural killer cell chemotaxis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005791	rough endoplasmic reticulum
GO:0030139	endocytic vesicle
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0043204	perikaryon
GO:0043679	axon terminus
GO:0044299	C-fiber
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm