Version 5.4
| Mus musculus Gene: Pvrl4 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-204508.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Pvrl4 | ||||||||
| Gene Name | poliovirus receptor-related 4 | ||||||||
| Synonyms | 1200017F15Rik; Prr4 | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Gene | ENSMUSG00000006411 | ||||||||
| Encoded Proteins |
poliovirus receptor-related 4
poliovirus receptor-related 4
poliovirus receptor-related 4
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143217:
This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 1:171370099-171388598 | ||||||||
| Strand | Forward strand | ||||||||
| Band | H3 | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||
| NETPATH | |||||||||
| REACTOME |
Cell-cell junction organization pathway
Adherens junctions interactions pathway
Nectin/Necl trans heterodimerization pathway
Cell junction organization pathway
Cell-Cell communication pathway
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| KEGG |
Adherens junction pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
Nectin/Necl trans heterodimerization pathway
Adherens junctions interactions pathway
Cell-Cell communication pathway
Cell junction organization pathway
Cell-cell junction organization pathway
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| KEGG |
Adherens junction pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | Q8R007 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 71740 | ||||||||
| UniGene | Mm.263414 | ||||||||
| RefSeq | NM_027893 NM_001122680 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS15493 CCDS48442 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| MGI ID | MGI:1918990 | ||||||||
| MGI Symbol | Pvrl4 | ||||||||
| EMBL | AF472510 AK004821 AK028479 AK154983 BC024948 | ||||||||
| GenPept | AAH24948 AAL79833 BAB23592 BAC25972 BAE32972 | ||||||||
| RNA Seq Atlas | 71740 | ||||||||