InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PVRL4

Summary

InnateDB Gene

IDBG-630217.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PVRL4

Gene Name

poliovirus receptor-related protein 4 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017877

Encoded Proteins

IDBP-681657

poliovirus receptor-related protein 4 precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143217:
This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:8421828-8438222

Strand

Forward strand

Band

Transcripts

ENSBTAT00000023767

ENSBTAP00000023767

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.