Version 5.4
Homo sapiens Gene: NR2C2
Summary
InnateDB Gene IDBG-20458.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NR2C2
Gene Name nuclear receptor subfamily 2, group C, member 2
Synonyms TAK1; TR4
Species Homo sapiens
Ensembl Gene ENSG00000177463
Encoded Proteins
IDBP-20460
nuclear receptor subfamily 2, group C, member 2
IDBP-244296
nuclear receptor subfamily 2, group C, member 2
IDBP-292775
nuclear receptor subfamily 2, group C, member 2
IDBP-365729
nuclear receptor subfamily 2, group C, member 2
IDBP-365734
nuclear receptor subfamily 2, group C, member 2
IDBP-365738
nuclear receptor subfamily 2, group C, member 2
IDBP-365750
nuclear receptor subfamily 2, group C, member 2
IDBP-365764
nuclear receptor subfamily 2, group C, member 2
IDBP-365768
nuclear receptor subfamily 2, group C, member 2
IDBP-809730
nuclear receptor subfamily 2, group C, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the nuclear hormone receptor family, such as NR2C2, act as ligand-activated transcription factors. The proteins have an N-terminal transactivation domain, a central DNA-binding domain with 2 zinc fingers, and a ligand-binding domain at the C terminus. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes (Yoshikawa et al., 1996 [PubMed 8661150]).[supplied by OMIM, Mar 2008]
This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:14947584-15053600
Strand Forward strand
Band p25.1
Transcripts
ENST00000323373 ENSP00000320447
ENST00000393102 ENSP00000376814
ENST00000406272 ENSP00000384463
ENST00000425241 ENSP00000388387
ENST00000413118 ENSP00000402272
ENST00000435454 ENSP00000391473
ENST00000437120 ENSP00000401807
ENST00000439011 ENSP00000412473
ENST00000413194 ENSP00000413438
ENST00000475707
ENST00000478572
ENST00000495282
ENST00000617312 ENSP00000483059
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
Experimentally validated
Total 41 [view]
Protein-Protein 40 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0003713 transcription coactivator activity
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007283 spermatogenesis
GO:0007399 nervous system development
GO:0010467 gene expression
GO:0021549 cerebellum development
GO:0030154 cell differentiation
GO:0040019 positive regulation of embryonic development
GO:0043401 steroid hormone mediated signaling pathway
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048520 positive regulation of behavior
GO:0051321 meiotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005893
View Gene Order
ENSBTAG00000013716
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_9
TNFalpha pathway
REACTOME
REACT_15525
Nuclear Receptor transcription pathway pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
ar_tf_pathway
Regulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL H7C3L1
UniProt Splice Variant
Entrez Gene 7182
UniGene Hs.555973 Hs.617839
RefSeq NM_001291694 NM_003298 XM_006713320
HUGO HGNC:7972
OMIM 601426
CCDS CCDS2621 CCDS74905
HPRD 03253
IMGT
EMBL AC090937 AC090954
GenPept
RNA Seq Atlas 7182

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca