Version 5.4
Mus musculus Gene: Fis1
Summary
InnateDB Gene IDBG-204681.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fis1
Gene Name fission 1 (mitochondrial outer membrane) homolog (yeast)
Synonyms 2010003O14Rik; Ttc11
Species Mus musculus
Ensembl Gene ENSMUSG00000019054
Encoded Proteins
IDBP-204683
fission 1 (mitochondrial outer membrane) homolog (yeast)
IDBP-258846
fission 1 (mitochondrial outer membrane) homolog (yeast)
IDBP-258848
fission 1 (mitochondrial outer membrane) homolog (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 5:136953275-136966234
Strand Forward strand
Band G2
Transcripts
ENSMUST00000019198 ENSMUSP00000019198
ENSMUST00000111097 ENSMUSP00000106726
ENSMUST00000111094 ENSMUSP00000106723
ENSMUST00000138610
ENSMUST00000147557
ENSMUST00000152658
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0000266 mitochondrial fission
GO:0000422 mitochondrion degradation
GO:0001836 release of cytochrome c from mitochondria
GO:0006626 protein targeting to mitochondrion
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008053 mitochondrial fusion
GO:0010821 regulation of mitochondrion organization
GO:0016559 peroxisome fission
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043653 mitochondrial fragmentation involved in apoptotic process
GO:0051260 protein homooligomerization
GO:0051561 positive regulation of mitochondrial calcium ion concentration
GO:0070584 mitochondrion morphogenesis
GO:0090141 positive regulation of mitochondrial fission
GO:0090314 positive regulation of protein targeting to membrane
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005779 integral component of peroxisomal membrane
GO:0016020 membrane
GO:0031307 integral component of mitochondrial outer membrane
GO:0043234 protein complex
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL G3X9U9
UniProt Splice Variant
Entrez Gene 66437
UniGene Mm.415628
RefSeq NM_001163243 NM_025562 XM_006504489
OMIM
CCDS CCDS51669 CCDS19757
HPRD
IMGT
MGI ID MGI:1913687
MGI Symbol Fis1
EMBL AC147987 CH466529
GenPept EDL19299
RNA Seq Atlas 66437

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca