InnateDB Protein
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IDBP-204683.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Fis1
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Protein Name
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fission 1 (mitochondrial outer membrane) homolog (yeast)
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Synonyms
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2010003O14Rik; Ttc11;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000019198
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InnateDB Gene
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IDBG-204681 (Fis1)
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Protein Structure
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Function |
Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin- related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. May be not essential for the assembly of functional fission complexes and the subsequent membrane scission event. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. {ECO:0000269PubMed:23283981}.
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Subcellular Localization |
Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0000266
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mitochondrial fission
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GO:0000422
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mitochondrion degradation
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GO:0001836
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release of cytochrome c from mitochondria
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GO:0006626
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protein targeting to mitochondrion
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GO:0007204
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positive regulation of cytosolic calcium ion concentration
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GO:0008053
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mitochondrial fusion
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GO:0010821
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regulation of mitochondrion organization
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GO:0016559
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peroxisome fission
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GO:0032471
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negative regulation of endoplasmic reticulum calcium ion concentration
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GO:0035584
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calcium-mediated signaling using intracellular calcium source
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GO:0043280
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positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
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GO:0043653
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mitochondrial fragmentation involved in apoptotic process
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GO:0051260
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protein homooligomerization
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GO:0051561
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positive regulation of mitochondrial calcium ion concentration
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GO:0070584
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mitochondrion morphogenesis
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GO:0090141
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positive regulation of mitochondrial fission
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GO:0090314
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positive regulation of protein targeting to membrane
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GO:2001244
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positive regulation of intrinsic apoptotic signaling pathway
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Cellular Component |
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PDB ID |
MGI:1913687
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InterPro |
IPR016543
Mitochondria fission 1 protein
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PFAM |
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PRINTS |
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PIRSF |
PIRSF008835
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9CQ92
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PhosphoSite |
PhosphoSite-Q9CQ92
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
66437
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UniGene |
Mm.415628
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RefSeq |
NP_079838
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MGI ID |
1IYG
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MGI Symbol |
Fis1
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OMIM |
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CCDS |
CCDS19757
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HPRD |
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IMGT |
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EMBL |
AK004479
AK004917
AK008078
AK008323
AK008916
BC010783
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GenPept |
AAH10783
BAB23324
BAB23668
BAB25445
BAB25601
BAB25966
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