Mus musculus Gene: Cldn15 | |||||||
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Summary | |||||||
InnateDB Gene | IDBG-204697.6 | ||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
Gene Symbol | Cldn15 | ||||||
Gene Name | claudin 15 | ||||||
Synonyms | 2210009B08Rik; BB107105 | ||||||
Species | Mus musculus | ||||||
Ensembl Gene | ENSMUSG00000001739 | ||||||
Encoded Proteins |
claudin 15
claudin 15
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Protein Structure | |||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||
Entrez Gene | |||||||
Summary |
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein increases permeability for sodium ions in anion-selective epithelial cell sheets. The gene deficiency leads to megaintestine and decreases in intestinal epithelial paracellular ion permeability. This gene is a direct target for hepatocyte-nuclear-factor-4alpha, a mediator of ion epithelial transport, and is down-modulated in inflammatory bowel disease. [provided by RefSeq, Aug 2010] |
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Gene Information | |||||||
Type | Protein coding | ||||||
Genomic Location | Chromosome 5:136966616-136975858 | ||||||
Strand | Forward strand | ||||||
Band | G2 | ||||||
Transcripts |
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Interactions | |||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||
NETPATH | |||||||
REACTOME | |||||||
KEGG |
Tight junction pathway
Cell adhesion molecules (CAMs) pathway
Leukocyte transendothelial migration pathway
Hepatitis C pathway
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INOH | |||||||
PID NCI | |||||||
Pathway Predictions based on Human Orthology Data | |||||||
NETPATH | |||||||
REACTOME |
Tight junction interactions pathway
Cell-Cell communication pathway
Cell junction organization pathway
Cell-cell junction organization pathway
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KEGG |
Cell adhesion molecules (CAMs) pathway
Leukocyte transendothelial migration pathway
Tight junction pathway
Hepatitis C pathway
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INOH | |||||||
PID NCI | |||||||
Cross-References | |||||||
SwissProt | |||||||
TrEMBL | |||||||
UniProt Splice Variant | |||||||
Entrez Gene | |||||||
UniGene | Mm.87202 | ||||||
RefSeq | NM_021719 | ||||||
OMIM | |||||||
CCDS | CCDS19758 | ||||||
HPRD | |||||||
IMGT | |||||||
MGI ID | |||||||
MGI Symbol | |||||||
EMBL | |||||||
GenPept | |||||||
RNA Seq Atlas | |||||||