Version 5.4
Homo sapiens Gene: CLDN15
Summary
InnateDB Gene IDBG-33221.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLDN15
Gene Name claudin 15
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000106404
Encoded Proteins
IDBP-33223
claudin 15
IDBP-295123
claudin 15
IDBP-384195
claudin 15
IDBP-384196
claudin 15
IDBP-384197
claudin 15
IDBP-807575
claudin 15
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:101232092-101238820
Strand Reverse strand
Band q22.1
Transcripts
ENST00000308344 ENSP00000308870
ENST00000401528 ENSP00000385300
ENST00000433833 ENSP00000405308
ENST00000414035 ENSP00000398418
ENST00000412417 ENSP00000390230
ENST00000433422
ENST00000463331
ENST00000611078 ENSP00000481925
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0042802 identical protein binding
Biological Process
GO:0006811 ion transport
GO:0016338 calcium-independent cell-cell adhesion
GO:0034329 cell junction assembly
GO:0045216 cell-cell junction organization
GO:0070830 tight junction assembly
Cellular Component
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0016021 integral component of membrane
GO:0016328 lateral plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001739
View Gene Order
ENSBTAG00000000345
Not yet available
Pathways
NETPATH
REACTOME
REACT_19373
Tight junction interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_19331
Cell-cell junction organization pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
hsa05160
Hepatitis C pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL C9JHQ4
UniProt Splice Variant
Entrez Gene 24146
UniGene Hs.38738
RefSeq NM_001185080 NM_014343
HUGO HGNC:2036
OMIM 615778
CCDS CCDS5717
HPRD 13065
IMGT
EMBL AC006329
GenPept
RNA Seq Atlas 24146

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca