Version 5.4
Mus musculus Gene: Apbb1
Summary
InnateDB Gene IDBG-204734.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Apbb1
Gene Name amyloid beta (A4) precursor protein-binding, family B, member 1
Synonyms Fe65; Rir
Species Mus musculus
Ensembl Gene ENSMUSG00000037032
Encoded Proteins
IDBP-204736
amyloid beta (A4) precursor protein-binding, family B, member 1
IDBP-789198
amyloid beta (A4) precursor protein-binding, family B, member 1
IDBP-789202
amyloid beta (A4) precursor protein-binding, family B, member 1
IDBP-789203
amyloid beta (A4) precursor protein-binding, family B, member 1
IDBP-789204
amyloid beta (A4) precursor protein-binding, family B, member 1
IDBP-789205
amyloid beta (A4) precursor protein-binding, family B, member 1
IDBP-789207
amyloid beta (A4) precursor protein-binding, family B, member 1
IDBP-789210
amyloid beta (A4) precursor protein-binding, family B, member 1
IDBP-789211
amyloid beta (A4) precursor protein-binding, family B, member 1
IDBP-789214
amyloid beta (A4) precursor protein-binding, family B, member 1
IDBP-789215
amyloid beta (A4) precursor protein-binding, family B, member 1
IDBP-789216
amyloid beta (A4) precursor protein-binding, family B, member 1
IDBP-789217
amyloid beta (A4) precursor protein-binding, family B, member 1
IDBP-789218
amyloid beta (A4) precursor protein-binding, family B, member 1
IDBP-789220
amyloid beta (A4) precursor protein-binding, family B, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166313:
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer\'s disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product\'s nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer\'s disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:105558483-105581653
Strand Reverse strand
Band E3
Transcripts
ENSMUST00000081165 ENSMUSP00000079932
ENSMUST00000191011 ENSMUSP00000140973
ENSMUST00000188368 ENSMUSP00000139788
ENSMUST00000190369 ENSMUSP00000140486
ENSMUST00000189072 ENSMUSP00000139575
ENSMUST00000191601 ENSMUSP00000140116
ENSMUST00000188001
ENSMUST00000189378 ENSMUSP00000140979
ENSMUST00000189265 ENSMUSP00000140137
ENSMUST00000187057 ENSMUSP00000139899
ENSMUST00000191250
ENSMUST00000186814
ENSMUST00000188440 ENSMUSP00000140715
ENSMUST00000187721 ENSMUSP00000140192
ENSMUST00000187683 ENSMUSP00000139426
ENSMUST00000187051 ENSMUSP00000139755
ENSMUST00000186868 ENSMUSP00000140052
ENSMUST00000190961
ENSMUST00000188726 ENSMUSP00000140822
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0035035 histone acetyltransferase binding
GO:0042393 histone binding
GO:0070064 proline-rich region binding
Biological Process
GO:0001764 neuron migration
GO:0006302 double-strand break repair
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007050 cell cycle arrest
GO:0007411 axon guidance
GO:0008542 visual learning
GO:0030048 actin filament-based movement
GO:0030198 extracellular matrix organization
GO:0030308 negative regulation of cell growth
GO:0043065 positive regulation of apoptotic process
GO:0043967 histone H4 acetylation
GO:0045665 negative regulation of neuron differentiation
GO:0045739 positive regulation of DNA repair
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050760 negative regulation of thymidylate synthase biosynthetic process
GO:0050821 protein stabilization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016607 nuclear speck
GO:0030027 lamellipodium
GO:0030426 growth cone
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000166313
View Gene Order
ENSBTAG00000015655
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05010
Alzheimer's disease pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa05010
Alzheimer's disease pathway
INOH
PID NCI
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 11785
UniGene
RefSeq NM_009685 XM_006507230 NM_001253885 NM_001253886 NM_001253887 XM_006507231 XM_006507232 XM_006507233 XM_006507234 XM_006507235 XM_006507236 XM_006507237
OMIM
CCDS
HPRD
IMGT
MGI ID MGI:107765
MGI Symbol Apbb1
EMBL
GenPept
RNA Seq Atlas 11785

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca