Version 5.4
Homo sapiens Gene: APBB1
Summary
InnateDB Gene IDBG-28785.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APBB1
Gene Name amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
Synonyms FE65; MGC:9072; RIR
Species Homo sapiens
Ensembl Gene ENSG00000166313
Encoded Proteins
IDBP-28787
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
IDBP-28789
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
IDBP-28793
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
IDBP-807928
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
IDBP-594868
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
IDBP-807939
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
IDBP-807940
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
IDBP-807892
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
IDBP-807901
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
IDBP-807908
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
IDBP-807911
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
IDBP-807914
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
IDBP-807930
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
IDBP-807932
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
IDBP-807942
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
IDBP-807943
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
IDBP-807945
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer\'s disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product\'s nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer\'s disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:6395124-6419414
Strand Reverse strand
Band p15.4
Transcripts
ENST00000299402 ENSP00000299402
ENST00000311051 ENSP00000311912
ENST00000389906 ENSP00000374556
ENST00000526240
ENST00000524626
ENST00000529519 ENSP00000477022
ENST00000530885 ENSP00000433338
ENST00000533407
ENST00000529778
ENST00000526925
ENST00000533139
ENST00000529890 ENSP00000476536
ENST00000534188
ENST00000532020 ENSP00000476647
ENST00000608655 ENSP00000476846
ENST00000608704 ENSP00000476871
ENST00000609360 ENSP00000477213
ENST00000608435 ENSP00000476776
ENST00000608394 ENSP00000476442
ENST00000608645 ENSP00000476646
ENST00000609331 ENSP00000477069
ENST00000610474 ENSP00000483682
ENST00000621678 ENSP00000481817
ENST00000618005 ENSP00000484493
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 84 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 84 [view]
Protein-Protein 83 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0042393 histone binding
GO:0070064 proline-rich region binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007050 cell cycle arrest
GO:0007165 signal transduction
GO:0007409 axonogenesis
GO:0030308 negative regulation of cell growth
GO:0043065 positive regulation of apoptotic process
GO:0043967 histone H4 acetylation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0050760 negative regulation of thymidylate synthase biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016607 nuclear speck
GO:0030027 lamellipodium
GO:0030426 growth cone
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037032
View Gene Order
ENSBTAG00000015655
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa05010
Alzheimer's disease pathway
INOH
PID NCI
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.372840
RefSeq NM_001164 NM_001257319 NM_001257320 NM_001257321 NM_001257323 NM_001257325 NM_001257326 NM_145689 XM_006718212 XM_006718214 XM_006718215 XM_006718216
HUGO
OMIM
CCDS CCDS31410 CCDS58114 CCDS66015 CCDS66016 CCDS66017 CCDS66018
HPRD 04087
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca