InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Scn10a

Summary

InnateDB Gene

IDBG-204799.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scn10a

Gene Name

sodium channel, voltage-gated, type X, alpha

Synonyms

Nav1.8; PN3; SNS

Species

Mus musculus

Ensembl Gene

ENSMUSG00000034533

Encoded Proteins

IDBP-204801

sodium channel, voltage-gated, type X, alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185313:
The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. [provided by RefSeq, Dec 2011]
The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:119608456-119719032

Strand

Reverse strand

Band

Transcripts

ENSMUST00000084787

ENSMUSP00000081845

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005248	voltage-gated sodium channel activity

Biological Process

GO:0002027	regulation of heart rate
GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0019228	neuronal action potential
GO:0019233	sensory perception of pain
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0055085	transmembrane transport
GO:0055117	regulation of cardiac muscle contraction
GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization
GO:0061337	cardiac conduction
GO:0086010	membrane depolarization during action potential
GO:0086067	AV node cell to bundle of His cell communication
GO:0086069	bundle of His cell to Purkinje myocyte communication

Cellular Component

GO:0001518	voltage-gated sodium channel complex
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030424	axon
GO:0044299	C-fiber
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000185313

View Gene Order

ENSBTAG00000046911

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_22266

Interaction between L1 and Ankyrins pathway

REACT_22205

L1CAM interactions pathway

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

K3W4P8

UniProt Splice Variant

Entrez Gene

20264

UniGene

Mm.247042

RefSeq

NM_001205321 NM_009134 XM_006511989 XM_006511990 XM_006511991 XM_006511992

OMIM

CCDS

CCDS57716

HPRD

IMGT

MGI ID

MGI:108029

MGI Symbol

Scn10a

EMBL

AC171201 CH466587

GenPept

EDL09206

RNA Seq Atlas

20264