InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Scn10a

Summary

InnateDB Protein

IDBP-204801.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scn10a

Protein Name

sodium channel, voltage-gated, type X, alpha

Synonyms

Nav1.8; PN3; SNS;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000081845

InnateDB Gene

IDBG-204799 (Scn10a)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005248	voltage-gated sodium channel activity

Biological Process

GO:0002027	regulation of heart rate
GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0019228	neuronal action potential
GO:0019233	sensory perception of pain
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0055085	transmembrane transport
GO:0055117	regulation of cardiac muscle contraction
GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization
GO:0061337	cardiac conduction
GO:0086010	membrane depolarization during action potential
GO:0086067	AV node cell to bundle of His cell communication
GO:0086069	bundle of His cell to Purkinje myocyte communication

Cellular Component

GO:0001518	voltage-gated sodium channel complex
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030424	axon
GO:0044299	C-fiber
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:108029

InterPro

IPR001696 Voltage gated sodium channel, alpha subunit
IPR003915 Polycystic kidney disease type 2 protein
IPR005821 Ion transport domain
IPR010526 Sodium ion transport-associated
IPR013122 Polycystin cation channel, PKD1/PKD2

PFAM

PF00520
PF06512
PF08016

PRINTS

PR00170
PR01433

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite