InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pex14

Summary

InnateDB Gene

IDBG-204872.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pex14

Gene Name

peroxisomal biogenesis factor 14

Synonyms

Pex14p; R75137

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028975

Encoded Proteins

IDBP-204874

peroxisomal biogenesis factor 14

IDBP-539899

peroxisomal biogenesis factor 14

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142655:
This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:148960535-149099876

Strand

Reverse strand

Band

Transcripts

ENSMUST00000103217	ENSMUSP00000099506
ENSMUST00000128067
ENSMUST00000154860
ENSMUST00000134747	ENSMUSP00000116791
ENSMUST00000148203

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	59 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0047485	protein N-terminus binding
GO:0048487	beta-tubulin binding

Biological Process

GO:0006461	protein complex assembly
GO:0007031	peroxisome organization
GO:0016558	protein import into peroxisome matrix
GO:0016560	protein import into peroxisome matrix, docking
GO:0016561	protein import into peroxisome matrix, translocation
GO:0032091	negative regulation of protein binding
GO:0034453	microtubule anchoring
GO:0036250	peroxisome transport along microtubule
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0044721	protein import into peroxisome matrix, substrate release
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051260	protein homooligomerization
GO:1901094	negative regulation of protein homotetramerization

Cellular Component

GO:0005622	intracellular
GO:0005730	nucleolus
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000142655

View Gene Order

ENSBTAG00000013538

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04146

Peroxisome pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04146

Peroxisome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.184172

RefSeq

NM_019781

OMIM

CCDS

CCDS18950

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas