Version 5.4
Bos taurus Gene: PEX14
Summary
InnateDB Gene IDBG-633112.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PEX14
Gene Name peroxisomal membrane protein PEX14
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013538
Encoded Proteins
IDBP-684799
peroxisomal biogenesis factor 14
IDBP-684800
peroxisomal biogenesis factor 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142655:
This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:43848339-43992183
Strand Reverse strand
Band
Transcripts
ENSBTAT00000045794 ENSBTAP00000043155
ENSBTAT00000018001 ENSBTAP00000018001
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.
Predicted by orthology
Total 54 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0047485 protein N-terminus binding
GO:0048487 beta-tubulin binding
Biological Process
GO:0006461 protein complex assembly
GO:0016558 protein import into peroxisome matrix
GO:0016560 protein import into peroxisome matrix, docking
GO:0016561 protein import into peroxisome matrix, translocation
GO:0032091 negative regulation of protein binding
GO:0034453 microtubule anchoring
GO:0036250 peroxisome transport along microtubule
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0044721 protein import into peroxisome matrix, substrate release
GO:0045892 negative regulation of transcription, DNA-templated
GO:0051260 protein homooligomerization
GO:1901094 negative regulation of protein homotetramerization
Cellular Component
GO:0005622 intracellular
GO:0005730 nucleolus
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000142655
View Gene Order
ENSMUSG00000028975
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04146
Peroxisome pathway
mmu04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A1L567 E1BFW8
UniProt Splice Variant
Entrez Gene 507393
UniGene Bt.103198
RefSeq NM_001080237 XM_005216951
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BT029854 DAAA02042987 DAAA02042988 DAAA02042989
GenPept ABM06109
RNA Seq Atlas 507393

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca