InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Epo

Summary

InnateDB Gene

IDBG-205003.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Epo

Gene Name

erythropoietin

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029711

Encoded Proteins

IDBP-205005

erythropoietin

IDBP-258968

erythropoietin

IDBP-258970

erythropoietin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130427:
This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:137483020-137533242

Strand

Reverse strand

Band

Transcripts

ENSMUST00000031723	ENSMUSP00000031723
ENSMUST00000111039	ENSMUSP00000106668
ENSMUST00000111038	ENSMUSP00000106667

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005128	erythropoietin receptor binding
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0030295	protein kinase activator activity

Biological Process

GO:0001525	angiogenesis
GO:0001666	response to hypoxia
GO:0003007	heart morphogenesis
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006915	apoptotic process
GO:0007566	embryo implantation
GO:0007568	aging
GO:0007584	response to nutrient
GO:0008284	positive regulation of cell proliferation
GO:0009651	response to salt stress
GO:0010523	negative regulation of calcium ion transport into cytosol
GO:0018105	peptidyl-serine phosphorylation
GO:0030218	erythrocyte differentiation
GO:0032496	response to lipopolysaccharide
GO:0033033	negative regulation of myeloid cell apoptotic process
GO:0033189	response to vitamin A
GO:0033574	response to testosterone
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042541	hemoglobin biosynthetic process
GO:0043066	negative regulation of apoptotic process
GO:0043249	erythrocyte maturation
GO:0043627	response to estrogen
GO:0045666	positive regulation of neuron differentiation
GO:0045740	positive regulation of DNA replication
GO:0045860	positive regulation of protein kinase activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046579	positive regulation of Ras protein signal transduction
GO:0048678	response to axon injury
GO:0051602	response to electrical stimulus
GO:0055008	cardiac muscle tissue morphogenesis
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0055093	response to hyperoxia
GO:0060979	vasculogenesis involved in coronary vascular morphogenesis
GO:0061032	visceral serous pericardium development
GO:0070555	response to interleukin-1
GO:0071474	cellular hyperosmotic response
GO:1902219	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
GO:1902251	negative regulation of erythrocyte apoptotic process
GO:2001258	negative regulation of cation channel activity