InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: EPO

Summary

InnateDB Gene

IDBG-640493.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPO

Gene Name

Erythropoietin

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003430

Encoded Proteins

IDBP-692761

Erythropoietin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130427:
This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:36409507-36411892

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000004450

ENSBTAP00000004450

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005128	erythropoietin receptor binding
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0030295	protein kinase activator activity

Biological Process

GO:0001666	response to hypoxia
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006915	apoptotic process
GO:0007566	embryo implantation
GO:0008284	positive regulation of cell proliferation
GO:0010523	negative regulation of calcium ion transport into cytosol
GO:0018105	peptidyl-serine phosphorylation
GO:0030218	erythrocyte differentiation
GO:0033033	negative regulation of myeloid cell apoptotic process
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042541	hemoglobin biosynthetic process
GO:0043066	negative regulation of apoptotic process
GO:0043249	erythrocyte maturation
GO:0045740	positive regulation of DNA replication
GO:0045860	positive regulation of protein kinase activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046579	positive regulation of Ras protein signal transduction
GO:0071474	cellular hyperosmotic response
GO:1902219	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
GO:1902251	negative regulation of erythrocyte apoptotic process
GO:2001258	negative regulation of cation channel activity