Mus musculus Gene: Pcolce
Summary
InnateDB Gene IDBG-205227.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pcolce
Gene Name procollagen C-endopeptidase enhancer protein
Synonyms Astt-2; Astt2; P14; PCPE-1
Species Mus musculus
Ensembl Gene ENSMUSG00000029718
Encoded Proteins
procollagen C-endopeptidase enhancer protein
procollagen C-endopeptidase enhancer protein
procollagen C-endopeptidase enhancer protein
procollagen C-endopeptidase enhancer protein
procollagen C-endopeptidase enhancer protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106333:
Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:137605103-137613784
Strand Reverse strand
Band G2
Transcripts
ENSMUST00000031731 ENSMUSP00000031731
ENSMUST00000054564 ENSMUSP00000057002
ENSMUST00000128755
ENSMUST00000146589
ENSMUST00000131703
ENSMUST00000136649
ENSMUST00000142675 ENSMUSP00000115654
ENSMUST00000124693 ENSMUSP00000120749
ENSMUST00000155251 ENSMUSP00000121575
ENSMUST00000148662
ENSMUST00000137210
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0008201 heparin binding
GO:0016504 peptidase activator activity
Biological Process
GO:0006508 proteolysis
GO:0010952 positive regulation of peptidase activity
Cellular Component
GO:0005615 extracellular space
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Collagen formation pathway
Collagen biosynthesis and modifying enzymes pathway
Extracellular matrix organization pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Crosslinking of collagen fibrils pathway
Assembly of collagen fibrils and other multimeric structures pathway
Collagen biosynthesis and modifying enzymes pathway
Extracellular matrix organization pathway
Collagen formation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D3YWH0 D3YZE3
UniProt Splice Variant
Entrez Gene 18542
UniGene Mm.262345
RefSeq NM_008788 XM_006504558
OMIM
CCDS CCDS39334
HPRD
IMGT
MGI ID MGI:105099
MGI Symbol Pcolce
EMBL AC124730
GenPept
RNA Seq Atlas 18542