InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atp1a4

Summary

InnateDB Gene

IDBG-205294.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp1a4

Gene Name

ATPase, Na+/K+ transporting, alpha 4 polypeptide

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000007107

Encoded Proteins

IDBP-258545

ATPase, Na+/K+ transporting, alpha 4 polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132681:
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:172223513-172258414

Strand

Reverse strand

Band

Transcripts

ENSMUST00000111243

ENSMUSP00000106874

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005391	sodium:potassium-exchanging ATPase activity
GO:0005524	ATP binding
GO:0015077	monovalent inorganic cation transmembrane transporter activity
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0006754	ATP biosynthetic process
GO:0006812	cation transport
GO:0006813	potassium ion transport
GO:0006814	sodium ion transport
GO:0007283	spermatogenesis
GO:0009566	fertilization
GO:0015672	monovalent inorganic cation transport
GO:0030317	sperm motility
GO:0030641	regulation of cellular pH
GO:0035725	sodium ion transmembrane transport
GO:0042391	regulation of membrane potential