Mus musculus Gene: Atp1a4
Summary
InnateDB Gene IDBG-205294.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atp1a4
Gene Name ATPase, Na+/K+ transporting, alpha 4 polypeptide
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000007107
Encoded Proteins
ATPase, Na+/K+ transporting, alpha 4 polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132681:
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:172223513-172258414
Strand Reverse strand
Band H3
Transcripts
ENSMUST00000111243 ENSMUSP00000106874
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005391 sodium:potassium-exchanging ATPase activity
GO:0005524 ATP binding
GO:0015077 monovalent inorganic cation transmembrane transporter activity
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0019829 cation-transporting ATPase activity
GO:0046872 metal ion binding
Biological Process
GO:0006754 ATP biosynthetic process
GO:0006812 cation transport
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0007283 spermatogenesis
GO:0009566 fertilization
GO:0015672 monovalent inorganic cation transport
GO:0030317 sperm motility
GO:0030641 regulation of cellular pH
GO:0035725 sodium ion transmembrane transport
GO:0042391 regulation of membrane potential
Cellular Component
GO:0005575 cellular_component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Ion channel transport pathway
Transmembrane transport of small molecules pathway
Ion transport by P-type ATPases pathway
KEGG
Cardiac muscle contraction pathway
Aldosterone-regulated sodium reabsorption pathway
Gastric acid secretion pathway
Protein digestion and absorption pathway
Carbohydrate digestion and absorption pathway
Salivary secretion pathway
Bile secretion pathway
Proximal tubule bicarbonate reclamation pathway
Pancreatic secretion pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Ion transport by P-type ATPases pathway
Transmembrane transport of small molecules pathway
Ion channel transport pathway
KEGG
Cardiac muscle contraction pathway
Aldosterone-regulated sodium reabsorption pathway
Proximal tubule bicarbonate reclamation pathway
Gastric acid secretion pathway
Pancreatic secretion pathway
Salivary secretion pathway
Bile secretion pathway
Protein digestion and absorption pathway
Carbohydrate digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt Q9WV27
TrEMBL Q91ZN9
UniProt Splice Variant
Entrez Gene 27222
UniGene Mm.482392
RefSeq NM_013734 XM_006496874
OMIM
CCDS CCDS48446
HPRD
IMGT
MGI ID MGI:1351335
MGI Symbol Atp1a4
EMBL AC074310 AC087061 AF164348 AF164349 AF164350 AF413667
GenPept AAD43812 AAD43813 AAD43814 AAL27700
RNA Seq Atlas 27222