Version 5.4
Homo sapiens Gene: ATP1A4
Summary
InnateDB Gene IDBG-103998.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP1A4
Gene Name ATPase, Na+/K+ transporting, alpha 4 polypeptide
Synonyms ATP1A1; ATP1AL2
Species Homo sapiens
Ensembl Gene ENSG00000132681
Encoded Proteins
IDBP-104000
ATPase, Na+/K+ transporting, alpha 4 polypeptide
IDBP-588722
ATPase, Na+/K+ transporting, alpha 4 polypeptide
IDBP-585581
ATPase, Na+/K+ transporting, alpha 4 polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:160151570-160186977
Strand Forward strand
Band q23.2
Transcripts
ENST00000368081 ENSP00000357060
ENST00000418334
ENST00000477338 ENSP00000434272
ENST00000469023
ENST00000466526
ENST00000470705 ENSP00000433094
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005391 sodium:potassium-exchanging ATPase activity
GO:0005524 ATP binding
GO:0015077 monovalent inorganic cation transmembrane transporter activity
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0019829 cation-transporting ATPase activity
GO:0046872 metal ion binding
Biological Process
GO:0006754 ATP biosynthetic process
GO:0006812 cation transport
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0007283 spermatogenesis
GO:0008152 metabolic process
GO:0009566 fertilization
GO:0015672 monovalent inorganic cation transport
GO:0015991 ATP hydrolysis coupled proton transport
GO:0030317 sperm motility
GO:0030641 regulation of cellular pH
GO:0034220 ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005890 sodium:potassium-exchanging ATPase complex
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000007107
View Gene Order
ENSBTAG00000038523
Not yet available
Pathways
NETPATH
REACTOME
REACT_25149
Ion transport by P-type ATPases pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
hsa04260
Cardiac muscle contraction pathway
hsa04960
Aldosterone-regulated sodium reabsorption pathway
hsa04964
Proximal tubule bicarbonate reclamation pathway
hsa04971
Gastric acid secretion pathway
hsa04972
Pancreatic secretion pathway
hsa04970
Salivary secretion pathway
hsa04976
Bile secretion pathway
hsa04974
Protein digestion and absorption pathway
hsa04973
Carbohydrate digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt Q13733
TrEMBL Q13818
UniProt Splice Variant
Entrez Gene 480
UniGene Hs.662219
RefSeq NM_144699 NM_001001734
HUGO HGNC:14073
OMIM 607321
CCDS CCDS1197 CCDS44255
HPRD 09541
IMGT
EMBL AF310646 AF352828 AF390027 AF421887 AF430843 AF459737 AF506797 AH002997 AK098076 AL121987 AY039031 BC028297 BC094801 M16796
GenPept AAA51800 AAA60941 AAH28297 AAH94801 AAK72396 AAL35818 AAL66357 AAM20793 AAQ07964 BAC05228 CAI15274
RNA Seq Atlas 480

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca