InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bcl2l11

Summary

InnateDB Gene

IDBG-205300.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bcl2l11

Gene Name

BCL2-like 11 (apoptosis facilitator)

Synonyms

1500006F24Rik; bcl2-L-11; Bim; Bod

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027381

Encoded Proteins

IDBP-205302

BCL2-like 11 (apoptosis facilitator)

IDBP-205304

BCL2-like 11 (apoptosis facilitator)

IDBP-205306

BCL2-like 11 (apoptosis facilitator)

IDBP-205308

BCL2-like 11 (apoptosis facilitator)

IDBP-260478

BCL2-like 11 (apoptosis facilitator)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153094:
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:128126038-128162547

Strand

Forward strand

Band

Transcripts

ENSMUST00000019281	ENSMUSP00000019281
ENSMUST00000089634	ENSMUSP00000087062
ENSMUST00000103211	ENSMUSP00000099500
ENSMUST00000103210	ENSMUSP00000099499
ENSMUST00000110341	ENSMUSP00000105970
ENSMUST00000146023
ENSMUST00000129206
ENSMUST00000132201

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	32 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001776	leukocyte homeostasis
GO:0001782	B cell homeostasis
GO:0001783	B cell apoptotic process
GO:0001822	kidney development
GO:0002260	lymphocyte homeostasis
GO:0002262	myeloid cell homeostasis
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007160	cell-matrix adhesion
GO:0007283	spermatogenesis
GO:0007420	brain development
GO:0008584	male gonad development
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009791	post-embryonic development
GO:0010942	positive regulation of cell death
GO:0030879	mammary gland development
GO:0032464	positive regulation of protein homooligomerization
GO:0034976	response to endoplasmic reticulum stress
GO:0035148	tube formation
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042981	regulation of apoptotic process
GO:0043029	T cell homeostasis
GO:0043065	positive regulation of apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043525	positive regulation of neuron apoptotic process
GO:0043583	ear development
GO:0045787	positive regulation of cell cycle
GO:0046620	regulation of organ growth
GO:0048066	developmental pigmentation
GO:0048070	regulation of developmental pigmentation
GO:0048536	spleen development
GO:0048538	thymus development
GO:0048563	post-embryonic organ morphogenesis
GO:0060139	positive regulation of apoptotic process by virus
GO:0060154	cellular process regulating host cell cycle in response to virus
GO:0070242	thymocyte apoptotic process
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:1902110	positive regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902263	apoptotic process involved in embryonic digit morphogenesis
GO:2000271	positive regulation of fibroblast apoptotic process
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005874	microtubule
GO:0019898	extrinsic component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0097140	BIM-BCL-xl complex
GO:0097141	BIM-BCL-2 complex