Mus musculus Gene: Mcm7 | |||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||
InnateDB Gene | IDBG-205861.6 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | Mcm7 | ||||||||||||||||||||||||
Gene Name | minichromosome maintenance deficient 7 (S. cerevisiae) | ||||||||||||||||||||||||
Synonyms | AI747533; mCDC47; Mcmd7 | ||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000029730 | ||||||||||||||||||||||||
Encoded Proteins |
minichromosome maintenance deficient 7 (S. cerevisiae)
minichromosome maintenance deficient 7 (S. cerevisiae)
minichromosome maintenance deficient 7 (S. cerevisiae)
minichromosome maintenance deficient 7 (S. cerevisiae)
minichromosome maintenance deficient 7 (S. cerevisiae)
minichromosome maintenance deficient 7 (S. cerevisiae)
minichromosome maintenance deficient 7 (S. cerevisiae)
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Protein Structure | |||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166508:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||
Genomic Location | Chromosome 5:138164583-138172422 | ||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||
Band | G2 | ||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 107 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||
REACTOME |
Cell Cycle, Mitotic pathway
Synthesis of DNA pathway
DNA strand elongation pathway
DNA Replication pathway
Unwinding of DNA pathway
Switching of origins to a post-replicative state pathway
Cell Cycle pathway
Cell Cycle Checkpoints pathway
Regulation of DNA replication pathway
Activation of the pre-replicative complex pathway
Orc1 removal from chromatin pathway
M/G1 Transition pathway
G2/M Checkpoints pathway
G1/S Transition pathway
Removal of licensing factors from origins pathway
Mitotic G1-G1/S phases pathway
Activation of ATR in response to replication stress pathway
DNA Replication Pre-Initiation pathway
Assembly of the pre-replicative complex pathway
S Phase pathway
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KEGG |
DNA replication pathway
Cell cycle pathway
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INOH | |||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||
NETPATH |
TNFalpha pathway
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REACTOME |
Activation of ATR in response to replication stress pathway
Orc1 removal from chromatin pathway
Removal of licensing factors from origins pathway
Switching of origins to a post-replicative state pathway
Unwinding of DNA pathway
Activation of the pre-replicative complex pathway
Assembly of the pre-replicative complex pathway
DNA Replication pathway
Synthesis of DNA pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
G2/M Checkpoints pathway
DNA Replication Pre-Initiation pathway
G1/S Transition pathway
Cell Cycle pathway
M/G1 Transition pathway
Cell Cycle, Mitotic pathway
DNA strand elongation pathway
Regulation of DNA replication pathway
Cell Cycle Checkpoints pathway
S Phase pathway
Mitotic G1-G1/S phases pathway
DNA Replication Pre-Initiation pathway
DNA Replication pathway
Assembly of the pre-replicative complex pathway
G1/S Transition pathway
Regulation of DNA replication pathway
Orc1 removal from chromatin pathway
Cell Cycle, Mitotic pathway
Synthesis of DNA pathway
Cell Cycle pathway
Unwinding of DNA pathway
M/G1 Transition pathway
G2/M Checkpoints pathway
Activation of the pre-replicative complex pathway
Activation of ATR in response to replication stress pathway
Removal of licensing factors from origins pathway
Cell Cycle Checkpoints pathway
Switching of origins to a post-replicative state pathway
DNA strand elongation pathway
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KEGG |
DNA replication pathway
Cell cycle pathway
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INOH | |||||||||||||||||||||||||
PID NCI |
ATR signaling pathway
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Cross-References | |||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||
TrEMBL | D3Z0J6 D3Z335 | ||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | 17220 | ||||||||||||||||||||||||
UniGene | Mm.378965 Mm.482227 | ||||||||||||||||||||||||
RefSeq | NM_008568 XM_006504556 | ||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||
CCDS | CCDS19793 | ||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
MGI ID | MGI:1298398 | ||||||||||||||||||||||||
MGI Symbol | Mcm7 | ||||||||||||||||||||||||
EMBL | AC151719 | ||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||
RNA Seq Atlas | 17220 | ||||||||||||||||||||||||