Version 5.4
Mus musculus Gene: Dusp14
Summary
InnateDB Gene IDBG-205913.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dusp14
Gene Name dual specificity phosphatase 14
Synonyms 1110014C10Rik; 2310042C07Rik; D11Ertd395e; MKP-L; Mkp6
Species Mus musculus
Ensembl Gene ENSMUSG00000018648
Encoded Proteins
IDBP-205915
dual specificity phosphatase 14
IDBP-205917
dual specificity phosphatase 14
IDBP-265243
dual specificity phosphatase 14
IDBP-541036
dual specificity phosphatase 14
IDBP-619958
dual specificity phosphatase 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:84048041-84069261
Strand Reverse strand
Band C
Transcripts
ENSMUST00000100705 ENSMUSP00000098271
ENSMUST00000018792 ENSMUSP00000018792
ENSMUST00000108101 ENSMUSP00000103736
ENSMUST00000138208 ENSMUSP00000120773
ENSMUST00000164891 ENSMUSP00000130624
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
null
View Gene Order
ENSBTAG00000010279
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.240885 Mm.475342 Mm.486673
RefSeq NM_019819 XM_006533796 XM_006533797 XM_006533798
OMIM
CCDS CCDS25182
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca